Welcome to the ACTIV‑6 study
Working together to help people with COVID-19 feel better faster.
For more information or to report a concern, call 833-385-1880 or complete this form.
ACTIV-6 has closed enrollment — participants are completing study activities and we will continue to analyze and share results.
Thank you to all who participated and supported the study!
Welcome to ACTIV‑6!
Thank you for your interest in ACTIV-6. We are truly grateful to clinical trial participants and researchers who have helped advance science and our understanding of treatments for COVID-19. The study has concluded enrollment, but you can view and share results and historical information about the study.
ACTIV-6 History and Accomplishments
ACTIV-6 is a unique study that allowed participants to take part from anywhere in the U.S. It opened enrollment in June 2021, and enrollment closed in April 2024. Here, you can view a timeline of the study’s history and milestone accomplishments.
Why This Study Is Important
Vaccines for COVID-19 are available, but access and uptake have been limited in some areas of the country. Additionally, more transmissible variants of the virus have emerged in the U.S. People are still getting sick with COVID-19, and many remain at risk for the disease.
Results from ACTIV-6 will help researchers understand how existing medications can improve symptoms and limit hospitalizations for people with mild-to-moderate COVID-19.
Medications in the ACTIV-6 Study
ACTIV-6 evaluated repurposed medications for effective, safe treatments for mild-to-moderate COVID-19. Repurposed medications are already approved by the U.S. Food and Drug Administration for other indications. The study tested these medications:
- Metformin (closed): an oral medication commonly used to treat diabetes
- Montelukast (closed): an oral anti-inflammatory medication commonly used to treat chronic asthma and for relief of seasonal
allergy symptoms - Fluticasone (closed): an inhaled steroid commonly prescribed to prevent and treat asthma
- Fluvoxamine (closed): a selective serotonin reuptake inhibitor (SSRI), often prescribed for depression
- Ivermectin (closed): a medication used to treat parasitic infections
