The ACTIV-6 Study

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ACTIV-6 may be for you if:

You are 30 or older and have mild-to-moderate COVID-19.

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What is the ACTIV-6 Study?

ACTIV-6 is a national study to find out whether certain medications approved by the U.S. Food & Drug Administration (FDA) can help people with mild-to-moderate COVID-19 feel better faster. The study will look at up to 7 medications, but you would only take one. There are no clinic visits in ACTIV-6. All study evaluations can be completed remotely, whether you’re at home or elsewhere, and medications are shipped directly to you.

Learn more about the history and progress of ACTIV-6.

Why Participate?

By participating in ACTIV-6, you will help us learn more about the best ways to treat other people with COVID-19 who have mild-to-moderate symptoms.

  • There are not many FDA-approved medications that can be taken at home to treat people with mild-to-moderate COVID-19.
  • Even with a successful vaccine strategy, thousands remain at risk for the virus.
  • Knowing how best to treat people with mild-to-moderate COVID could help them feel better faster.

Is the ACTIV-6 Study Right for Me?

You may be a good match for the ACTIV-6 study if you meet the basic 3 requirements:

  • Are 30 years old or older.
  • Tested positive for COVID-19 within the past 10 days.
  • Have at least 2 COVID-19 symptoms for 7 days or less. Symptoms include fatigue, difficulty breathing, fever, cough, nausea, vomiting, diarrhea, body aches, chills, headache, sore throat, nasal symptoms, and/or new loss of sense of taste or smell.
Learn more about the ACTIV-6 Study

What can I expect if I participate?

  • Shortly after entering the study, you will receive a study kit in the mail that includes your medicine.
  • Take your study medicine as instructed.
  • For the next 14 days, fill out daily questionnaires online about how you’re doing taking the medicine, any new or better symptoms, and other quality of life issues.
  • On Day 14, study personnel will contact you to ask more questions about how you’re doing. This is done remotely and does not require a clinic visit.
  • On Day 28, study personnel will contact you to ask additional questions about how you’re doing. This is done remotely and does not require a clinic visit.
  • On Days 90, 120, and 180, fill out a symptom survey and a questionnaire about your quality of life. This is done remotely and does not require a clinic visit.